HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-bromo-4-(trifluoromethyl)- → 8-methyl-3-(4-trifluoromethylphenyl)-8-azabicyclo[3.2.1]octan-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reactant | Npc164516 | HCID 79038 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 8-methyl-3-(4-trifluoromethylphenyl)-8-azabicyclo[3.2.1]octan-3-ol | HCID 435094 | — |
Reaction Steps
The title compound was prepared from 4-bromobenzotrifluoride, n-butyllithium in hexanes (31.2 mL, 2.5M; 77.9 mmol) and 8-methyl-8-azabicyclo[3.2.1]octan-3-one (5 g, 36 mmol). Yield 6.2 g (60%) as a yellow solid, m.p. 189.2-190.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100275 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-929f452864cf4b2e8dd3a31d4b43e485 |
| Source note | uspto-grants-2000_08 |