HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 1,5-Diazabicyclo(4.3.0)non-5-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Nitroethane | HCID 6587 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1,5-Diazabicyclo(4.3.0)non-5-ene | HCID 76349 | — |
| Product | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
Reaction Steps
In Step 2, ester 24 is reacted with a substituted or unsubstituted nitroalkane, such as nitromethane or nitroethane, in a polar aprotic solvent, such as acetonitrile, THF or the like, preferably acetonitrile, in the presence of an amine base, such as DBU, DBN, triethylamine or the like, preferably DBU, at a temperature from 0° to 80° C., preferably 25° C., for 24 h to yield nitro ester 25. ##STR29##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100279 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-4ee7b72a8e064a389b503bcda804e972 |
| Source note | uspto-grants-2000_08 |