HCID 18694219, compound → HCID 10990514, compound

Participants

Reaction Steps

Methyl 4'-((4-chlorobutanoyl)amino)-2'-methylbiphenyl-4-carboxylate (D3) (1.65 g, 4.8 mmol) was stirred in dry dimethylformamide (DMF) (20 ml) as potassium t-butoxide (0.70 g, 5.7 mmol) was added. The mixture was stirred for 30 min, diluted with ethyl acetate (200 ml), washed successively with brine, water and brine, dried (Na2SO4) and evaporated to give a light brown gum. Chromatography on silica gel, eluting with 0-50% ether/dichloromethane, gave the title compound (1.15 g, 71%) as a light yellow solid.

Provenance & Evidence