Diethyl Ether → HCID 18694253, compound

Participants

Reaction Steps

Methyl 4'-(4,5-dihydro-2-oxoimidazol-1-yl)-2'-methylbiphenyl-4-carboxylate (D18) (0.208 g, 0.67 mmol) was stirred in dry DMF (5 ml). Potassium t-butoxide (0.10 g, 0.82 mmol) and iodomethane (0.065 ml, 1.0 mmol) were added. The mixture was stirred for 1 h, diluted with ethyl acetate, washed with water and brine, dried (Na2SO4) and evaporated to give a gum. Chromatography on silica eluting with 50% ether in dichloromethane gave the title compound (0.205 g, 94%) as a white solid.

Provenance & Evidence