Methyl iodide → HCID 18694294, compound

Participants

Reaction Steps

A stirred solution of 2'-methyl-4'-(3-methyl-2-oxopyrrolidin-1-yl)biphenyl-4-carboxylic acid (D21, 0.35 g, 0.0011 mole) in DMF (5 ml) at 25° C. was treated with anhydrous potassium carbonate (0.27 g, 0.0020 mole) and iodomethane (0.08 ml, 0.0014 mole). The mixture was stirred for 3 hours, then diluted with water (100 ml) and extracted with ethyl acetate (2×100 ml). The combined extract was washed with water (2×100 ml), then dried (Na2SO4) and concentrated in vacuo to afford the title compound as a beige solid (0.35 g, 99%).

Provenance & Evidence