HCID 18694259, compound → HCID 18694272, compound

HRID 1870899Notes

Reaction equation

HRID 1870899 reaction equation
[C:1]([N:5]1[CH2:10][CH:9]=[C:8]([CH2:11][OH:12])[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[C:13]([N:16]1[C:24]2[C:19](=[CH:20][C:21](O)=[C:22]([Br:25])[CH:23]=2)[CH2:18][CH2:17]1)(=[O:15])[CH3:14]>>[C:13]([N:16]1[C:24]2[C:19](=[CH:20][C:21]([O:12][CH2:11][C:8]3[CH2:9][CH2:10][N:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:6][CH:7]=3)=[C:22]([Br:25])[CH:23]=2)[CH2:18][CH2:17]1)(=[O:15])[CH3:14]

Participants

3

Reactant 2

HCID 18694259HCID 18694259, compoundHCID 219483801-(6-Bromo-5-hydroxy-2,3-dihydro-1H-indol-1-yl)ethan-1-one

Product 1

HCID 18694272HCID 18694272, compound

Procedure

The title compound was prepared from 1-tert-butyl-1,2,3,6-tetrahydropyridine-4-methanol (D58) and 1-acetyl-6-bromo-2,3-dihydroindol-5-ol (Tetrahedron, 1973, 29 (8), 1115) using the method outlined in Description 8a in WO 96/19477 (68%).

Sources & evidence

ORD record
ord-a2276b72f8d845a999236aac859bf871
Source dataset
uspto-grants-2000_08
Patent number
US06100272

Reaction notes

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