HCID 18694249, compound → HCID 70287160, compound

Participants

Reaction Steps

A stirred solution of 1'-methyl-2,3,5,6-tetrahydrospiro[furo[3,2-f]indole-3,4'-piperidine] (D67, 1.0 g, 4.1 mmole) in dichloromethane (70 ml) at room temp. under argon was treated with manganese dioxide (0.68 g, 8.2 mmole). The mixture was stirred for 18 hours, then additional manganese dioxide was added (0.30 g, 2.4 mnmole). The mixture was stirred for an additional 24 hours, then filtered through a pad of kieselguhr and the filtrate concentrated under vacuum. The two components present were separated by chromatography on neutral alumina. Elution with ether gave the title compound as a white solid (0.41 g, 41%), further elution with ethyl acetate gave the second component.

Provenance & Evidence