1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → HCID 86755589, compound

HRID 1870907Notes

Reaction equation

HRID 1870907 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8](OC)=[O:9])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][CH2:20][C:19]2=[O:23])=[C:14]([CH3:24])[CH:13]=1.[CH3:25][N:26]1[CH2:31][CH2:30][C:29]2([C:42]3[C:34](=[CH:35][C:36]4[CH2:37][CH2:38][NH:39][C:40]=4[CH:41]=3)[O:33][CH2:32]2)[CH2:28][CH2:27]1>>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([CH:27]2[CH2:28][C:29]3([C:42]4[C:34](=[CH:35][C:36]5[CH2:37][CH2:38][NH:39][C:40]=5[CH:41]=4)[O:33][CH2:32]3)[CH2:30][CH2:31][N:26]2[CH3:25])=[O:9])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][CH2:20][C:19]2=[O:23])=[C:14]([CH3:24])[CH:13]=1

Participants

3

Reactant 2

HCID 106579521'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]HCID 18694289HCID 18694289, compound

Product 1

HCID 86755589HCID 86755589, compound

Procedure

The title compound was prepared from methyl 2,3'-dimethyl-4'-(2-oxopyrrolidin-1-yl)biphenyl-4-carboxylate (D32) and 1'-methyl-2,3,6,7-tetrahydrospiro[filro[2,3-f]indole-3,4'-piperidine] (D7) following the method of Example 1. This was obtained as a yellow oil (77%), which was converted to its hydrochloride salt, crystallising from acetone.

Sources & evidence

ORD record
ord-514244f048a54fa1bf55027e4d43816f
Source dataset
uspto-grants-2000_08
Patent number
US06100272

Reaction notes

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