1'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine] → HCID 18694304, compound

HRID 1870913Notes

Reaction equation

HRID 1870913 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:8]=[CH:7][C:6]=1[C:17]1[CH:22]=[CH:21][C:20]([C:23](O)=[O:24])=[CH:19][CH:18]=1)=[O:4].[CH3:26][N:27]1[CH2:32][CH2:31][C:30]2([C:43]3[C:35](=[CH:36][C:37]4[CH2:38][CH2:39][NH:40][C:41]=4[CH:42]=3)[O:34][CH2:33]2)[CH2:29][CH2:28]1>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:8]=[CH:7][C:6]=1[C:17]1[CH:22]=[CH:21][C:20]([C:23]([N:40]2[C:41]3[CH:42]=[C:43]4[C:30]5([CH2:33][O:34][C:35]4=[CH:36][C:37]=3[CH2:38][CH2:39]2)[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]5)=[O:24])=[CH:19][CH:18]=1)=[O:4]

Participants

3

Reactant 2

HCID 106579521'-Methyl-6,7-dihydro-2H,5H-spiro[furo[2,3-f]indole-3,4'-piperidine]HCID 18694281HCID 18694281, compound

Product 1

HCID 18694304HCID 18694304, compound

Procedure

The title compound was prepared from 2'-methoxycarbonyl-4'-(2-oxopyrrolidin-1-yl)biphenyl-4-carboxylic acid (D53) and 1'-methyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (D7) following a similar procedure to Example 15 as an off-white powder (66%).

Sources & evidence

ORD record
ord-49246042f3ff47248cf91779646798ae
Source dataset
uspto-grants-2000_08
Patent number
US06100272

Reaction notes

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