2'-Methyl-4'-(2-oxopyrrolidin-1-yl)[1,1'-biphenyl]-4-carboxylic acid → HCID 18694298, compound

HRID 1870914Notes

Reaction equation

HRID 1870914 reaction equation
[C:1]([N:5]1[CH2:10][CH2:9][C:8]2([C:21]3[C:13](=[CH:14][C:15]4[CH2:16][CH2:17][NH:18][C:19]=4[CH:20]=3)[O:12][CH2:11]2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[CH3:22][C:23]1[CH:28]=[C:27]([N:29]2[CH2:33][CH2:32][CH2:31][C:30]2=[O:34])[CH:26]=[CH:25][C:24]=1[C:35]1[CH:40]=[CH:39][C:38]([C:41](O)=[O:42])=[CH:37][CH:36]=1>>[C:1]([N:5]1[CH2:6][CH2:7][C:8]2([C:21]3[C:13](=[CH:14][C:15]4[CH2:16][CH2:17][N:18]([C:41]([C:38]5[CH:37]=[CH:36][C:35]([C:24]6[CH:25]=[CH:26][C:27]([N:29]7[CH2:33][CH2:32][CH2:31][C:30]7=[O:34])=[CH:28][C:23]=6[CH3:22])=[CH:40][CH:39]=5)=[O:42])[C:19]=4[CH:20]=3)[O:12][CH2:11]2)[CH2:9][CH2:10]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 230052992'-Methyl-4'-(2-oxopyrrolidin-1-yl)[1,1'-biphenyl]-4-carboxylic acidHCID 53700170HCID 53700170, compound

Product 1

HCID 18694298HCID 18694298, compound

Procedure

The title compound was prepared from 1'-tert-butyl-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine) (D61) and 2'-methyl-4'-(2-oxopyrrolidin-1-yl)biphenyl-4-carboxylic acid (D47) using the method outlined in Example 15.

Sources & evidence

ORD record
ord-50e2d938cc8f435bb78757739768f561
Source dataset
uspto-grants-2000_08
Patent number
US06100272

Reaction notes

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