Ammonia → HCID 1511, compound

HRID 1870942Notes

Reaction equation

HRID 1870942 reaction equation
[NH3:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:10]2[NH:14][C:13]3[CH:15]=[CH:16][CH:17]=[C:18]([C:19]([O:21]C)=O)[C:12]=3[N:11]=2)[CH:7]=[CH:8][CH:9]=1>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:10]2[NH:14][C:13]3[CH:15]=[CH:16][CH:17]=[C:18]([C:19]([NH2:1])=[O:21])[C:12]=3[N:11]=2)[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 10569296HCID 10569296, compound

Product 1

HCID 1511HCID 1511, compoundYield 46%

Procedure

Following standard procedure C, a liquid ammonia solution of methyl 2-(3'-methoxyphenyl)-1-H-benzimidazole-4-carboxylate (203 mg, 0.596 mmol) was heated under constant volume. The solid residue was recrystallised from methanol to give the pure product (73.5 mg, 46%).

Workup

  1. customThe solid residue was recrystallised from methanol

Sources & evidence

ORD record
ord-30660af18869496b9386ef72e79fa846
Source dataset
uspto-grants-2000_08
Patent number
US06100283

Reaction notes

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