HCID 54008280, compound → HCID 53933380, compound

Participants

Reaction Steps

A solution of (R)-5-benzyloxy-3-(1-methyl-2-pyrrolidinylmethyl)-1-phenylsulfonylindole (Example 7e, 2.01 g, 4.36 mmol) and 10% Pd/C (0.64 g, 0.436 mmol) in ethanol (25 mL) was stirred under an atmosphere of H2. Filtration to remove the catalyst followed by flash chromatography (silica gel) yielded (R)-5-hydroxy-3-(1-methyl-2-pyrrolidinylmethyl)-1-phenylsulfonylindole (1.5 g, 93%; HRMS-FAB+ : C20H22N2O3S, calculated MH+ :371.14294; found MH+ :371.14081).

Provenance & Evidence