Potassium Carbonate → HCID 54381333, compound

Participants

Reaction Steps

A solution of (R)-5-hydroxy-3-(1-methyl-2-pyrrolidinylmethyl)-1-phenylsulfonylindole (Example 10, 74 mg, 0.20 mmol) and iodobenzene (61.2 mg, 0.3 mmol) with K2CO3 (41.4 mg 0.30 mmol), CuBr (17.2 0.12 mmol) and Cu powder (10 mg, 0.15 mmol) in NMP (0.7 mL) was heated at 170° C. Aqueous workup and flash chromatography (silica gel) yielded (R)-3-(1-methyl-2-pyrrolidinylmethyl)5-phenoxy-1-phenylsulfonylindole (5.8 mg, 8%, HRMS-FAB+ : C26H26N2O3S, calculated MH+ :447.17422; found MH+ : 447.17240).

Provenance & Evidence