HCID 9822354, compound → HCID 54053863, compound

HRID 1870979Notes

Reaction equation

HRID 1870979 reaction equation
[O:1]1[C:6]2[C:7]3[CH2:13][CH2:12][CH2:11][C:8]=3[CH:9]=[CH:10][C:5]=2[CH2:4][CH2:3][CH:2]1[CH2:14][NH:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]1[N:25]=[CH:24][CH:23]=[CH:22][N:21]=1.[O:26]1C(CNCCCNC2N=CC=CN=2)CCC2C=CC3C(OCCC=3)C1=2.O1C(CNCCCNC2N=CC=CN=2)CCC2C=CC3CCCCC=3C1=2.N1CCN=C1NCCCNCC1CCC2C=CC3CCCC=3C=2O1.O1C(CNCCCNC2NCCCN=2)CCC2C=CC3CCCOC=3C1=2.O1C2C3CCCC=3C=CC=2CCC1CNCCCNC1NCCCN=1.O1C2C3OC(CNCCCNC4NCCCN=4)CCC=3C=CC=2OCC1.O1C(CNCCCNC2NCCCN=2)CCC2C=CC3CCCCC=3C1=2.FC1C=C(C=CC(OC)=O)C2OC(CNCCCNC3N=CC=CN=3)CCC=2C=1.FC1C=C(C2OC=CC=2)C2OC(CNCCCNC3N=CC=CN=3)CCC=2C=1.FC1C=C(C2SC=CC=2)C2OC(CNCCCNC3NCCCN=3)CCC=2C=1.O1C2C=CC=CC=2CCC1CNCCCNC1CCCCN=1.O1C2C=CC=CC=2CCC1CNCCCNC1C=CN=C(NC)N=1>>[O:1]1[CH:2]([CH2:14][NH:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]2[N:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH2:3][CH2:4][C:5]2[CH:10]=[CH:9][C:8]3[CH2:11][CH2:12][CH2:13][O:26][C:7]=3[C:6]1=2

Participants

14

Reactant 13

HCID 9822354HCID 9822354, compoundHCID 18694133HCID 18694133, compoundHCID 18694135HCID 18694135, compoundHCID 18694141HCID 18694141, compoundHCID 18694145HCID 18694145, compoundHCID 18694147HCID 18694147, compoundHCID 18694157HCID 18694157, compoundHCID 18694159HCID 18694159, compoundHCID 18694165HCID 18694165, compoundHCID 18694192HCID 18694192, compoundHCID 53901931HCID 53901931, compoundHCID 54513743HCID 54513743, compoundHCID 86753236HCID 86753236, compound

Product 1

HCID 54053863HCID 54053863, compound

Procedure

N-[(2,3,4,7,8,9-hexahydrocyclopenta[h]-1-benzopyran-2-yl)methyl]-N'-2-pyrimidinyl-1,3-propanediamine; (±)-N-[(2,3,4,8,9,10-hexahydrobenzo[2,1-b:3,4-b']dipyran-2-yl)methyl]-N'-2-pyrimidinyl-1,3-propane diamine; N-[(3,4,7,8,9,10-hexahydro-2H-naphtho[1,2-b]pyran-2-yl)methyl]-N'-2-pyrimidinyl-1,3-propanediamine; N-(4,5-dihydro-1H-imidazol-2-yl)-N'-[(2,3,4,7,8,9-hexahydrocyclopenta[h]-1-benzopyran-2-yl)methyl]-1,3-propanediamine; N-[(2,3,4,7,8,9-hexahydrobenzo[2,1-b:3,4-b']dipyran-2-yl)methyl]-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1,3-propanediamine; N-[(2,3,4,7,8,9-hexahydrocyclopenta[h]-1-benzopyran-2-yl)methyl]-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1,3-propanediamine; N-[(2,3,7,8-tetrahydro-9H-pyrano[2,3-f]-1,4-benzodioxin-9-yl)methyl]-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1,3-propanediamine; N-[(3,4,7,8,9,10-hexahydro-2H-naphtho[1,2-b]pyran-2-yl)methyl]-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1,3-propanediamine; methyl 3-[6-fluoro-3,4-dihydro-2-[[[3-(2-pyrimidinylamino)propyl]amino]methyl]-2H-1-benzopyran-8-yl]-2-propenoate; N-[[6-fluoro-8-(2-furanyl)-3,4-dihydro-2H-1-benzopyran-2-yl]methyl]-N'-2-pyrimidinyl-1,3-propanediamine; N-[[6-fluoro-3,4-dihydro-8-(2-thienyl)-2H-1-benzopyran-2-yl]methyl]-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1,3-propanediamine; N-[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl]-N'-(3,4,5,6-tetrahydro-2-pyridinyl)-1,3-propanediamine; N4 -[3-[[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl]amino]propyl]-N2-methyl-2,4-pyrimidinediamine, the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof.

Sources & evidence

ORD record
ord-dfa0edb2aff843d9a66ff9903a5c9e72
Source dataset
uspto-grants-2000_08
Patent number
US06100268

Reaction notes

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