1,3-Propanediamine → HCID 18694139, compound

HRID 1870997Notes

Reaction equation

HRID 1870997 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[CH2:9]([NH2:13])[CH2:10][CH2:11][NH2:12].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:12][CH2:11][CH2:10][CH2:9][NH2:13])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 4281,3-PropanediamineHCID 10340Sodium CarbonateHCID 673313,6-Dichloropyridazine

Product 1

HCID 18694139HCID 18694139, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3,6-dichloropyridazine (0.168 mol), 1,3-propanediamine (0.84 mol) and sodium carbonate (0.17 mol) in ethanol (500 ml) was stirred and refluxed overnight. The reaction mixture was filtered over dicalite. The filtrate was evaporated. The residue was crystallized from acetonitrile. The crystals were filtered off and dried, yielding 20.7 g of N-(6-chloro-3-pyridazinyl)-1,3-propanediamine; mp. 124.9° C. (interm. 1-c).

Workup

  1. temperaturerefluxed overnight
  2. filtrationThe reaction mixture was filtered over dicalite
  3. customThe filtrate was evaporated
  4. customThe residue was crystallized from acetonitrile
  5. filtrationThe crystals were filtered off
  6. customdried

Sources & evidence

ORD record
ord-dcf8efb893fe41b8817032bd75ed1433
Source dataset
uspto-grants-2000_08
Patent number
US06100268

Reaction notes

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