Ammonia → HCID 18694134, compound

Participants

Reaction Steps

A mixture of intermediate (16-c) (0.12 mol) in methanol saturated with ammonia (500 ml) was hydrogenated with Raney nickel (6 g) as a catalyst After uptake of hydrogen (2 eq.), the catalyst was filtered off and the filtrate was evaporated. The residue was purified by distillation, yielding 24 g (90.8%) of (±)-N-[(3,4-dihydro-2H-benzopyran-2-yl)methyl]-1,3-propanediamine (interm. 17-c).

Provenance & Evidence