HuagongsheHuagongshe Chemistry Print Report · For research reference only
Norchlorcyclizine → Cetirizine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Norchlorcyclizine | HCID 9340 | — |
| Reactant | Methyl 2-(2-chloroethoxy)acetate | HCID 15337474 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Cetirizine methyl ester | HCID 608480 | — |
Reaction Steps
10 gr. of (0.035 mole) of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 8.06 gr. (0.0525 mole) of methyl 2-chloroethoxyacetate and 50 ml. of triethylamine were introduced into a pressure vessel and treated in a similar way as described in example 1. 12.5 gr. of methyl [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetate is obtained as reddish oil (88.7% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100400 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-950f1ae5ba8a4647af578eb869f7464a |
| Source note | uspto-grants-2000_08 |