HuagongsheHuagongshe Chemistry Print Report · For research reference only
Norchlorcyclizine → Cetirizine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Norchlorcyclizine | HCID 9340 | — |
| Reactant | Ethyl 2-(2-chloroethoxy)acetate | HCID 10964894 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Cetirizine ethyl ester | HCID 9844843 | 90.8% |
Reaction Steps
10 gr. (0.035 mole) of 1-[(4-chlorophenyl)phenylmethyl]piperazine, 8.8 gr. of ethyl 2-chloroethoxyacetate, 0.4. gr. of tetrabutylammonium iodide and 50 ml. of triethylamine were introduced into a pressure vessel and treated as described in example 1. 13.2 gr. of ethyl [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetate is obtained (90.8% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100400 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-77086cb68edd41a7bb03b3a213a00040 |
| Source note | uspto-grants-2000_08 |