HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylaniline → HCID 10219937, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylaniline | HCID 7515 | — |
| Reactant | 4-Chlorobenzonitrile | HCID 12163 | — |
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 10219937 | HCID 10219937 | 92% |
Reaction Steps
The above general procedure was followed using 4-chlorobenzonitrile (137 mg, 1.00 mmol) and N-methylaniline (107 mg, 1.00 mmol) with 1 mol % Pd(dba)2 and 0.8 mol % tri-t-butylphosphine in 1.0 mL of toluene. After 12 hours, the reaction mixture was adsorbed onto silica gel and chromatographed with 10% ethyl acetate/hexanes to give 191 mg (92%) of N-(4-cyanophenyl)-N-methylaniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06100398 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-d7d890596b2f4e098d7c772eaf7c19fa |
| Source note | uspto-grants-2000_08 |