反应详情

16.3 ml of ethyl bromopyruvate were added dropwise to 15.9 g of the product of Stage B in 250 ml of ethanol and the mixture was refluxed for 5 hours. The solvent was evaporated under reduced pressure and the residue was chromatographed on silica (eluant: hexane-AcOEt 1-1) to obtain 10.2 g of the expected product melting at 69.1° C.

1. temperaturethe mixture was refluxed for 5 hours
2. customThe solvent was evaporated under reduced pressure
3. customthe residue was chromatographed on silica (eluant: hexane-AcOEt 1-1)