Ethylamine → HCID 86584735, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of lovastatin (5.0 g, 0.012 mol) and 2N solution of ethylamine in tetrahydrofuran (37 ml, 0.074 mol) was heated to gentle reflux at 70° C. for 10 hours. The solution was cooled to ambient temperature and ethyl acetate (100 ml) was added; the mixture was washed with 2N hydrochloric acid (3×50 ml). The combined aqueous layers were washed with ethyl acetate (100 ml) and the combined organic layers with water (2×100 ml). The organic layer was dried over sodium sulphate, filtered and evaporated at reduced pressure to give an orange oil.

Provenance & Evidence