Adenosine → HCID 135412808, compound

Participants

Reaction Steps

114 mg of the crude anomer mixture of 9-(2-deoxy-2-fluoro-4-thio-D-arabinofuranosyl)-2,6-diaminopurine (beta/alpha=1.55) obtained in Synthesis Example 2 was suspended in 25 ml of tris hydrochloric acid buffer solution (pH=7.0). To this suspension was added 0.43 ml (100 units) of adenosine deaminase, and the mixture was stirred at room temperature for 6 hours. The reaction solution was purified by ODS reverse phase column chromatography to obtain 48 mg (yield 48%) of the title compound.

Provenance & Evidence