Methyl iodide → HCID 18690791, compound

Participants

Reaction Steps

To a solution of potassium tert-butoxide (Fluka, 0.45 g, 4 mmole) and of 5-tert-butyl-2-indancarbaldehyde (ex. 4; 0.71 g, 3.5 mmole), there was added at room temperature and under N2, methyl iodide (0.56 g, 4 mmole) and reaction was allowed at room temperature, under stirring. The mixture was taken in ether and washed with NH4Cl and brine, dried over Na2SO4 and concentrated (0,9 g). Chromatography on SiO2 (30 g), with toluene as eluting agent, provided 50 mg (purity>99%, yield 7%) of the desired aldehyde.

Provenance & Evidence