反应详情

The title compound was prepared according to the procedure in Example 5, step 2 using 2'-methoxy-[1,1';3',1"]terphenyl-5'-carboxylic acid (1.031 g, 3.388 mmol), oxalyl chloride (0.325 mL, 3.727 mmol), commercial 2-ethylbenzofuran (0.4953 g, 3.388 mmol) and tin (IV) chloride (0.436 mL, 3.727 mmol) in CH2Cl2. Purification on Biotage KP-Sil eluting with 3% EtOAc/pet. ether gave 1.070 g, (73%) of the title compound. 1H NMR (DMSO-d6) δ 1.24 (t, 3 H), 2.90 (quartet, 2 H), 3.21 (s, 3 H), 7.30-7.67 (m, 14 H), 7.75 (s, 2 H).

1. customThe title compound was prepared
2. customPurification on Biotage KP-Sil
3. washeluting with 3% EtOAc/pet. ether