4-(Chlorosulfonyl)-2-hydroxybenzoic acid → HCID 9827065, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure in Example 4 using 4-[2-(2-butyl-benzofuran-3-yl)-ethyl]-phenol (0.410 g, 1.36 mmol) and 4-chlorosulphonyl-2-hydroxybenzoic acid (0.644 g, 2.72 mmol). Purification on 2% H3PO4 /MeOH treated silica gel, eluting with EtOAc/hexane gave 0.571 g (85%) of the title compound as a light brown solid, mp 93-95° C. 1H NMR consistent. mass spectrum (-ESI) m/z 493 (M-H).

Provenance & Evidence