(4-tert-Butylphenyl)hydrazine → (cis)-4-(3,4-Dimethoxyphenyl)-2-(4-tert-butylphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

HRID 1871394Notes

Reaction equation

HRID 1871394 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][NH2:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:13][O:14][C:15]1[CH:16]=[C:17]([C:23]2[C@H:32]3[C@H:27]([CH2:28][CH2:29][CH2:30][CH2:31]3)[C:26](=[O:33])N(CCO)N=2)[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]>>[CH3:13][O:14][C:15]1[CH:16]=[C:17]([C:23]2[C@H:32]3[C@H:27]([CH2:28][CH:29]=[CH:30][CH2:31]3)[C:26](=[O:33])[N:11]([C:8]3[CH:7]=[CH:6][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:10][CH:9]=3)[N:12]=2)[CH:18]=[CH:19][C:20]=1[O:21][CH3:22]

Participants

3

Reactant 2

HCID 2773676(4-tert-Butylphenyl)hydrazineHCID 86755609(cis)-4-(3,4-Dimethoxyphenyl)-2-(2-hydroxy-1-ethyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 70003894(cis)-4-(3,4-Dimethoxyphenyl)-2-(4-tert-butylphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

Procedure

Prepared from 4-tert-butylphenylhydrazine and compound C as described for compound 35. After evaporation of the solvent, the compound was crystallized from ethanol. M.p. 197°-199° C.

Workup

  1. customAfter evaporation of the solvent
  2. customthe compound was crystallized from ethanol

Sources & evidence

ORD record
ord-6d401784beab4f7a9a3fbe15e36d1205
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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