o-Chlorophenylhydrazine hydrochloride → (cis)-4-(3,4-Dimethoxyphenyl)-2-(4-Chlorophenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

HRID 1871395Notes

Reaction equation

HRID 1871395 reaction equation
[Cl:1][C:2]1[CH:7]=CC=[CH:4][C:3]=1NN.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([C:20]2[C@H:29]3[C@H:24]([CH2:25][CH2:26][CH2:27][CH2:28]3)[C:23](=[O:30])[N:22]([CH2:31][CH2:32]O)[N:21]=2)[CH:15]=[CH:16][C:17]=1[O:18][CH3:19]>>[CH3:10][O:11][C:12]1[CH:13]=[C:14]([C:20]2[C@H:29]3[C@H:24]([CH2:25][CH:26]=[CH:27][CH2:28]3)[C:23](=[O:30])[N:22]([C:31]3[CH:32]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:21]=2)[CH:15]=[CH:16][C:17]=1[O:18][CH3:19]

Participants

3

Reactant 2

HCID 418422o-Chlorophenylhydrazine hydrochlorideHCID 86755609(cis)-4-(3,4-Dimethoxyphenyl)-2-(2-hydroxy-1-ethyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 70004066(cis)-4-(3,4-Dimethoxyphenyl)-2-(4-Chlorophenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

Procedure

Prepared from 2-chlorophenylhydrazine and compound C as described for compound 35. M.p. 140°-141° C.

Sources & evidence

ORD record
ord-73b575fafb9a4d3f913a2ba0ebb2d3b3
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

Loading…