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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1871411Generated: November 3, 2026

4-(Chloromethyl)phenylacetic acid → (cis)-4-(4-(3,4-Dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydro-1H-phthalazin-2-ylmethyl)phenylacetic acid

https://huagongshe.com/reaction/1871411

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)phenylacetic acidHCID 10313419—
Reactant(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneHCID 10913208—
Reactant(cis)-4-(4-(3,4-Dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydro-1H-phthalazin-2-ylmethyl)-benzoic acidHCID 86755615—
Product(cis)-4-(4-(3,4-Dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydro-1H-phthalazin-2-ylmethyl)phenylacetic acidHCID 86755619—

Reaction Steps

Prepared from compound 1 and 4-chloromethylphenylacetic acid as described for compound 83. Purified by chromatography (ethyl acetate). Crystallized from diethyl ether. M.p. 164°-166° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06103718
Source datasetuspto-grants-2000_08
ORD IDord-4e4e23ef578d45d598c8954b27af2275
Source noteuspto-grants-2000_08