3-(Chloromethyl)pyridine hydrochloride → HCID 70003286, compound

HRID 1871422Notes

Reaction equation

HRID 1871422 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl.[N:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][Cl:30])[CH:24]=1>>[ClH:30].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:29][C:25]3[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 70003286HCID 70003286, compound

Procedure

Prepared from compound 1 and 3-picolylchloride hydrochloride as described for compound 105. Purified by chromatography (dichloromethane). Crystallized from diethyl ether as the hydrochloride. M.p. 192°-195° C.

Workup

  1. customPurified by chromatography (dichloromethane)
  2. customCrystallized from diethyl ether as the hydrochloride

Sources & evidence

ORD record
ord-f7ad21274ea54ebfa259afb9646dc193
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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