4-(Chloromethyl)pyridinium chloride → HCID 70004242, compound

HRID 1871424Notes

Reaction equation

HRID 1871424 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl.[N:23]1[CH:28]=[CH:27][C:26]([CH2:29]Cl)=[CH:25][CH:24]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:29][C:26]3[CH:27]=[CH:28][N:23]=[CH:24][CH:25]=3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 745704-(Chloromethyl)pyridinium chlorideHCID 10935039cis-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

Product 1

HCID 70004242HCID 70004242, compound

Procedure

Prepared from compound 3 and 4-picolylchloride hydrochloride as described for compound 105. Purified by chromatography (ethyl acetate). Crystallized from diethyl ether. M.p. 121°-124° C.

Workup

  1. customPurified by chromatography (ethyl acetate)
  2. customCrystallized from diethyl ether

Sources & evidence

ORD record
ord-65d5d6a3bad0433a81af44d679f41ea2
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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