4-(Chloromethyl)-2-methyl-1,3-thiazole → HCID 70003970, compound

HRID 1871429Notes

Reaction equation

HRID 1871429 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].ClC[C:24]1[N:25]=[C:26]([CH3:29])[S:27][CH:28]=1.C(N1N=C(C2C=CC(OC)=C(OC)C=2)[C@H]2[C@H](CCCC2)C1=O)C1C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[N:13]([C:24]3[N:25]=[C:26]([CH3:29])[S:27][CH:28]=3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 3

HCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazoleHCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneHCID 70001660(cis)-2-Benzyl-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 70003970HCID 70003970, compound

Procedure

Prepared from compound 1 and 4-chloromethyl-2-methylthiazole as described for compound 78. Crystallized from ethyl acetate. M.p. 135°-137° C.

Workup

  1. customCrystallized from ethyl acetate

Sources & evidence

ORD record
ord-5f1ff46323ef452b8b35e757d05c64ea
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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