Imidazole → HCID 86755624, compound

HRID 1871436Notes

Reaction equation

HRID 1871436 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:22][CH2:23][CH2:24][CH2:25]Br)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[NH:27]1[CH:31]=[CH:30][N:29]=[CH:28]1.[ClH:32].COC1C=C(C2[C@H]3[C@H](CCCC3)C(=O)N(CCN3C=CN=C3)N=2)C=CC=1OC>>[ClH:32].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:22][CH2:23][CH2:24][CH2:25][N:27]3[CH:31]=[CH:30][N:29]=[CH:28]3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 3

HCID 795ImidazoleHCID 70003567HCID 70003567, compoundHCID 86755621HCID 86755621, compound

Product 1

HCID 86755624HCID 86755624, compound

Procedure

Prepared from compound 114 and imidazole as described for compound 113. The reaction mixture was evaporated and the residue dissolved in 2N HCl. After extraction with dichloromethane and drying over magnesium sulfate, the solvent was evaporated. The residue crystallized on treating with ethyl acetate. M.p. 192°-194° C.

Workup

  1. customThe reaction mixture was evaporated
  2. dissolutionthe residue dissolved in 2N HCl
  3. extractionAfter extraction with dichloromethane
  4. dry with materialdrying over magnesium sulfate
  5. customthe solvent was evaporated
  6. customThe residue crystallized
  7. additionon treating with ethyl acetate

Sources & evidence

ORD record
ord-5d67d36e2307450e8619804f9266b3dc
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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