Imidazole → HCID 86755627, compound

HRID 1871438Notes

Reaction equation

HRID 1871438 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]Br)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[NH:29]1[CH:33]=[CH:32][N:31]=[CH:30]1.[ClH:34].COC1C=C(C2[C@H]3[C@H](CCCC3)C(=O)N(CCN3C=CN=C3)N=2)C=CC=1OC>>[ClH:34].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH:17]=[CH:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][N:29]3[CH:33]=[CH:32][N:31]=[CH:30]3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 3

HCID 795ImidazoleHCID 70003567HCID 70003567, compoundHCID 86755626HCID 86755626, compound

Product 1

HCID 86755627HCID 86755627, compound

Procedure

Prepared from compound 117 and imidazole as described for compound 113. Purified by chromatography and crystallized as the hydrochloride from tetrahydrofurane. M.p. 183° C.

Workup

  1. customPurified by chromatography
  2. customcrystallized as the hydrochloride from tetrahydrofurane

Sources & evidence

ORD record
ord-fbbae68ccb09490ba38dd028e1551d83
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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