HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → (cis)-4-(4-Methoxy-3-hydroxyphenyl)-2-cyclopentyl-4a,5,8,8a-tetrahydro-2H-phthalazin-1one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | (cis)-4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-cyclopentyl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one | HCID 70002575 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (cis)-4-(4-Methoxy-3-hydroxyphenyl)-2-cyclopentyl-4a,5,8,8a-tetrahydro-2H-phthalazin-1one | HCID 70120964 | — |
Reaction Steps
A solution of 3.3 g of compound 21 and 2 g of p-toluenesulfonic acid in 15 ml of toluene was refluxed for 4 h. After cooling to room temperature, themixture was washed with aqueous sodium carbonate, the toluene solution was dried over magnesium sulfate and evaporated. Crystallization from diethyl ether/petroleum ether (60-80° C.). M.p. 142-144° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06103718 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-60bd47dee38a4e45ace687d8f6ee846c |
| Source note | uspto-grants-2000_08 |