4-Iodotoluene → HCID 18691567, compound

Participants

Reaction Steps

4-benzyl-2-oxazolidinone (5 g, 28 mmol), potassium nitrate (2.9 g, 29 mmol) and p-iodotoluene (0.5 g, 2 mmol) were stirred in trifluoracetic acid (50 ml) overnight. The mixture was then poured onto ice and extracted with ethyl acetate. This was washed with sodium bicarbonate solution, dried (Mg SO4) and evaporated. Flash chromatography (70:30 ethyl acetate/hexane) gave the product (2.2 g, 35%) Mpt 150-151° C., MS (ES) 223 (M+1)+

Provenance & Evidence