2-Chloro-4-fluorobenzene-1-sulfonyl chloride → HCID 9885737, compound

HRID 1871521Notes

Reaction equation

HRID 1871521 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][CH:23](C(OC(C)(C)C)=O)[CH2:24][CH3:25])=[CH:16][CH:15]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9]([NH:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][NH:22][CH2:23][CH2:24][CH3:25])=[CH:18][CH:19]=1)(=[O:11])=[O:10]

Participants

3

Reactant 2

HCID 5228462-Chloro-4-fluorobenzene-1-sulfonyl chlorideHCID 18691624HCID 18691624, compound

Product 1

HCID 9885737HCID 9885737, compound

Procedure

Using procedure 4, 2-chloro-4-fluorobenzenesulfonyl chloride was added to 2-(4-aminophenyl)ethyl-1-(tert-butoxycarbonyl)propylamine to give the title compound as a solid, m.p. 165-167° C.

Sources & evidence

ORD record
ord-cc94dd5578d144bfadf4942aa4e1c27e
Source dataset
uspto-grants-2000_08
Patent number
US06103766

Reaction notes

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