Methanol → HCID 53807098, compound

Participants

Reaction Conditions

Reaction Steps

2.00 ml of a 1N aqueous sodium hydroxide solution was added to a mixture of 350 mg of methyl 2-phenylthio-3-[4-[2-[[1-[4(2-pyridyl)phenyl]ethylidene]aminoxy]ethoxy]phenyl]propionate obtained in Example 3, 3 ml of methanol and 2 ml of dioxane, and the mixture was stirred at 50° C. for 4 hours. After the reaction, the reaction mixture was concentrated and diluted with water. Then, the pH of the reaction mixture was adjusted to a value of 3 with 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated to obtain 324 mg of the desired compound as a foamy solid.

Provenance & Evidence