Sodium Hydroxide → HCID 54529682, compound

HRID 1871634Notes

Reaction equation

HRID 1871634 reaction equation
[C:1]1([NH:7][CH:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][O:24][N:25]=[C:26]([C:28]3[CH:33]=[CH:32][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:30][CH:29]=3)[CH3:27])=[CH:17][CH:16]=2)[C:9]([O:11]CC)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([NH:7][CH:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][O:24][N:25]=[C:26]([C:28]3[CH:29]=[CH:30][C:31]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=4)=[CH:32][CH:33]=3)[CH3:27])=[CH:17][CH:16]=2)[C:9]([OH:11])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54509846HCID 54509846, compound

Product 1

HCID 54529682HCID 54529682, compoundYield 91%

Procedure

The reaction was carried out according to Example 4 using 260 mg of ethyl 2-phenylamino-3-[4-[2-[[1-[4-(2-pyridyl)phenyl]ethylidene]aminoxy]ethoxy]phenyl]propionate obtained in Example 5 and 1.00 ml of a 1N aqueous sodium hydroxide solution. After the reaction, the reaction mixture was concentrated and diluted with water. The pH of the reaction mixture was adjusted to a value of 4 with 1N hydrochloric acid, and precipitate was obtained by filtration. The precipitate was washed with water and isopropyl ether to obtain 224 mg of the desired compound.

Workup

  1. customAfter the reaction
  2. concentrationthe reaction mixture was concentrated
  3. additiondiluted with water
  4. customprecipitate was obtained by filtration
  5. washThe precipitate was washed with water and isopropyl ether

Sources & evidence

ORD record
ord-76016bf15f0043619959616f3f07e94e
Source dataset
uspto-grants-2000_08
Patent number
US06103907

Reaction notes

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