Potassium Hydroxide → HCID 54395706, compound

Participants

Reaction Conditions

Reaction Steps

0.67 g of potassium hydroxide was added to a solution of 1.20 g of ethyl 2-(3-phenylpropyl)-3-[4-[2-[[1-[4(2-pyridyl)phenyl]ethylidene]aminoxy]ethoxy]phenyl]propionate obtained in Example 19 in 20 ml of ethanol, and the mixture was stirred at 80° C. for 2 hours. After the reaction, the reaction mixture was concentrated. To the residue were added water, ice and ethyl acetate and the pH of the reaction mixture was adjusted to a value of 4 with 3N hydrochloric acid. Then, the ethyl acetate layer was separated. The extract thus obtained was dried over anhydrous magnesium sulfate and then evaporated under reduced pressure to obtain 1.10 g of the desired compound as a gum.

Provenance & Evidence