HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 69894216, compound → HCID 69895611, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 69894216 | HCID 69894216 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 69895611 | HCID 69895611 | 84.8% |
Reaction Steps
182 mg (0.3 mmol) (R)-1-[8-[(R)-2-benzyloxycarbonyl-pyrrolidin-1-yl]-2,7-dimethoxy-8-oxo-octanoyl]-pyrrolidine-2-carboxylic acid benzyl ester in 10 ml methanol were hydrogenated in the presence of 30 mg 5% Pd on carbon. Filtration and evaporation of the solvent yielded 109 mg (84%) (R)-1-[8-[(R)-2- carboxy-pyrrolidin-1-yl]-2,7-dimethoxy-8-oxo-octanoyl]-pyrrolidine-2-carboxylic acid as colorless oil. MS: 427 (M-H)-.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06103910 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-986f29c77d224419bb155ce3fff156b1 |
| Source note | uspto-grants-2000_08 |