Potassium tert-butoxide → HCID 54495068, compound

Participants

Reaction Steps

To a solution of 595 mg (5.3 mmol) potassium tert-butylate in 4 ml dimethylformamide at room temperature was added dropwise a solution of 420 mg (2.5 mmol) 3,5-dihydroxybenzoate in 4 ml dimethylformamide. Stirring was continued for 2-3 min and a solution of 1.46 mg (5.0 mmol) (R)- (1)-bromoacetyl-pyrrolidine-2-carboxylic acid tert-butyl ester in 5 ml dimethylformamide was added within 1-2 min. The reaction mixture was stirred for additional 2 h at room temperature. The solvent was removed in vacuo and the residue purified by flash-chromatography to yield 1.01 g (68%) of the title compound as a colorless oil. MS m/e (%): 608 (M+NH4+, 92), 591 (M+H+, 48), 535 (41), 479 (100).

Provenance & Evidence