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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1871742Generated: November 3, 2026

benzyl (2R)-pyrrolidine-2-carboxylate hydrochloride → HCID 178525082, compound

https://huagongshe.com/reaction/1871742

Reaction equation

Participants

RoleNameHCIDCharge
Reactantbenzyl (2R)-pyrrolidine-2-carboxylate hydrochlorideHCID 22827650—
ReactantHCID 178525731HCID 178525731—
SolventEthyl AcetateHCID 8857—
ProductHCID 178525082HCID 17852508276%

Reaction Steps

Using General Procedure A with 2.0 g (8.2 mmol) D-Proline benzyl ester hydrochloride and 700 mg (4.1 mmol) trans-cyclohexane-1,4-dicarboxylic acid afforded, after flash chromatography (EtOAc), 1.67 g (76%) of the title compound as a colorless oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06103910
Source datasetuspto-grants-2000_08
ORD IDord-bbf39e8938ce42c98ec5435f4b0b6684
Source noteuspto-grants-2000_08