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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1871747Generated: November 2, 2026

Isophthalic Acid → HCID 53657616, compound

https://huagongshe.com/reaction/1871747

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsophthalic AcidHCID 8496—
Reactantbenzyl (2R)-pyrrolidine-2-carboxylate hydrochlorideHCID 22827650—
SolventEthyl AcetateHCID 8857—
ProductHCID 53657616HCID 5365761672.1%

Reaction Steps

Using General Procedure A with 5.8 g (24.0 mmol) D-Proline benzyl ester hydrochloride and 2.0 g (12.0 mmol) benzene-1,3-dioic acid afforded, after flash chromatography (EtOAc), 4.68 g (72%) of the title compound as a yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06103910
Source datasetuspto-grants-2000_08
ORD IDord-acc60ed2be6746caafddaefa78d0cd05
Source noteuspto-grants-2000_08