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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1871748Generated: November 1, 2026

2,6-Pyridinedicarboxylic acid → HCID 54082754, compound

https://huagongshe.com/reaction/1871748

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Pyridinedicarboxylic acidHCID 10367—
Reactantbenzyl (2R)-pyrrolidine-2-carboxylate hydrochlorideHCID 22827650—
SolventEthyl AcetateHCID 8857—
ProductHCID 54082754HCID 5408275477%

Reaction Steps

Using General Procedure A with 5.8 g (24.0 mmol) D-Proline benzyl ester hydrochloride and 2.0 g (12.0 mmol) pyridine-2,6-dicarboxylic acid afforded, after flash chromatography (EtOAc), 5.0 g (77%) of the title compound as a yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06103910
Source datasetuspto-grants-2000_08
ORD IDord-9aa7ee0d327c412f8f795bf7d10babb0
Source noteuspto-grants-2000_08