関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | P-Cresol | HCID 2879 | — |
| 反応物 | Acetic acid, benzoyldiazo-, ethyl ester | HCID 605325 | — |
| 触媒 | Acetic acid, rhodium(2+) salt | HCID 21674 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Ethyl alpha-(4-Methylphenyl)benzoylacetate | HCID 54208493 | 26.1% |
反応手順
A mixture of 7.66 g of ethyl α-diazobenzoylacetate, 3.8 g of p-cresol and 150 mg of rhodium(II) acetate in 40 cc of carbon tetrachloride was stirred at a temperature of 40-50° C. for 2 hours. After cooling, the insoluble materials were filtered off and the solvent was distilled off. The crude product thus obtained was purified by a silica gel column chromatography (eluent: chloroform/hexane=1/2) to obtain 2.59 g of compound E. Yield: 24.7%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | USRE036832 |
|---|
| 出典データセット | uspto-grants-2000_08 |
|---|
| ORD ID | ord-bcc469dc8195417ab2dc4d2ed6c9b70a |
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| 出典メモ | uspto-grants-2000_08 |
|---|
