Chloroacetic Acid → HCID 15285305, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.9 g of compound G and 7.8 g of chloroacetic acid was stirred at 120° C. for 10 hours. After cooling, water was added to the reaction mixture and the precipitate formed was collected by filtration. The precipitate was dissolved in ethyl acetate and washed with water. The solution was dried over magnesium sulfate and distilled to remove the solvent. The crude product thus obtained was washed with ether to obtain 4.45 g of 5-chloro-3-(2-chlorophenyl)-1-benzothiophen-2-carboxylic acid. Yield: 83.3%.

Provenance & Evidence