Diethyl Pyrocarbonate → Morphine

Participants

Reaction Steps

A lipid component containing DEPC, rather than DOPC, was prepared as in Example 1. The first aqueous component contained 17 mg/mL of morphine sulfate (Mallinckrodt Chemical Inc., St. Louis, Mo.) in 10 mM hydrochloric acid, and 0.2, 2.5 or 5.0 w/v % of sucrose as osmotic excipient. The remainder of the steps described in Example 1 were carried out to obtain MVLs containing morphine sulfate suspended in normal saline. The estimated osmolarity (mOsm), percent yield, and drug loading of these formulations are shown in Table 5 below:

Provenance & Evidence