Chloroform → HCID 131721944, compound

HRID 1871836Notes

Reaction equation

HRID 1871836 reaction equation
[CH3:1][O:2][P:3]([O:12][CH3:13])([CH2:5][CH2:6][C:7]([NH:9][CH2:10][OH:11])=[O:8])=[O:4].[CH:14]([Cl:17])([Cl:16])[Cl:15]>>[CH3:1][O:2][P:3]([O:12][CH3:13])([CH2:5][CH2:6][C:7]([NH:9][CH2:10][OH:11])=[O:8])=[O:4].[CH:14]([Cl:17])([Cl:16])[Cl:15]

Participants

3

Reactant 2

HCID 6212ChloroformHCID 29959Dimethyl (3-((hydroxymethyl)amino)-3-oxopropyl)phosphonate

Product 1

HCID 131721944HCID 131721944, compound

Procedure

A 10 g of PA was dissolved into a 200 cm3 of chloroform and a 12.8 g of MDPA was slowly added thereto. Then, the solution was stirred for 2 hours at room temperature. After the completion of the reaction in the solution, the raw materials were removed by means of a silica gel column to obtain a 500 cm3 of PA-MDPA/chloroform solution. The solution was then condensed to 100 cm3 and washed with a 50 cm3 of water for three times. Then, it was dried with magnesium sulfate and, after drying, the chloroform was removed to produce a 16.4 g of PA-MDPA.

Workup

  1. customAfter the completion of the reaction in the solution
  2. customthe raw materials were removed by means of a silica gel column

Sources & evidence

ORD record
ord-407abbc529f242829f1dcc9533ad6d16
Source dataset
uspto-grants-2000_08
Patent number
US06106906

Reaction notes

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