Lawesson's reagent → 6-Chloro-5-hydroxy-2,2-dimethyl-benzofurane-3-thione

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Reaction Steps

A solution of 20 mmol 6-chloro-5-hydroxy-2,2-dimethyl-benzofuran-3-one in 30 ml toluene is admixed with 10 mmol Lawesson's reagent and heated for 3 hours to boiling under reflux. After cooling to room temperature it is filtered on 50 g silica gel. The red fraction of the filtrate is collected. After removing the toluene by distillation a red oil remains.

Provenance & Evidence