Hydrochloric Acid → HCID 53918214, compound

Participants

Reaction Steps

Lithium borohydride (102 mg, 4.22 mmol) was added under ice-cooling to 22 ml of a ethanolic solution of 780 mg (2.11 mmol) of Compound C obtained in Reference Example 1, followed by stirring at room temperature for 1.5 hours. The reaction solution was adjusted to pH 3 with 1N hydrochloric acid, and then extracted three times with chloroform. The extract was washed with saturated saline and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained crude product was recrystallized from acetonitrile to give 440 mg (yield 56%) of Compound D as white prisms.

Provenance & Evidence